chapter 7 - 2/26/2008 "Linkage and Chromosome Mapping...

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2/26/2008 1 “Linkage and Chromosome Mapping in Eukaryotes” Linkage versus independent assortment Incomplete linkage/crossing over Three point mapping Many genes reside on each chromosome. Unless they are separated by crossing over, alleles at the loci on each homolog segregate as a unit during gamete formation. Recombinant gametes resulting from crossing over enhance genetic variability within a species and serve as the basis for constructing chromosome maps. Chromosome #1 Human Linkage versus Independent Assortment 1. There are many more genes than chromosomes in and organism Sutton And Boveri, 1903. 2. Each chromosome contains literally hundreds or thousands of genes (depending on the length of the chromosome). When we discuss linkage we refer to the inheritance patterns for two or more genes. 3. Genes (alleles) that are located on the same chromosome and are inherited together are said to be “Linked ”. 4. Because chromosomes are the unit of transmission, genes (alleles) located together along the length of the chromosome are inherited together. 5. Genes that are located along the chromosome(s) can be mapped to better understand where they are located in the genome and understand which traits can be expected to be inherited together.
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2/26/2008 2 Linkage Options 1. Two genes are located on different chromosomes The genes will always be Unlinked 2. Two genes are located on the same chromosome are said to be Syntenic . They can be: a. Linked assort together b. Unlinked assort independently If genes are located on different chromosomes, they assort (segregate) independently according to Mendel’s fourth postulate! Segregation causes alleles to assort
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This note was uploaded on 04/12/2008 for the course SORC 330 taught by Professor Brick during the Spring '08 term at Colorado State.

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chapter 7 - 2/26/2008 "Linkage and Chromosome Mapping...

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