BIOL 445 Chapter 4

BIOL 445 Chapter 4 - by contact with self antigens 1....

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The BIG PICTURE (Above) Stages of B-Cell Development
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1. Stem Cell 2. Pro-B 3. Pre-B 4. Immature 5. Mature 6. Early stages are in contact with bone marrow stromal cells
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- B-cell survival depends on productive gene re-arrangements
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- Some re-arrangements have a second chance to be productive
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-Cell-surface expression of the products of rearranged immunoglobulins genes prevents further gene rearrangement
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-The proteins involved in immunoglobulin-gene rearrangement are developmentally controlled
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-Many B-cell tumors carry chromosomal translocations that join immunoglobulin genes to genes regulating cell growth -Translocations, oncogenes and proto-oncogenes
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- B cells expressing the glycoprotein CD5 express a distinctive repertoire of receptors
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-Selection and further development of the B-cell repertoire -Self-reactive immature B cells are eliminated or inactivated
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Unformatted text preview: by contact with self antigens 1. Anergy 2. Clonal Deletion 3. Receptor Editing, 2 possibilities-Receptor Editing-Mature naive B cells compete for access to lymphoid follicles-Follicle space is limited, those that do not gain access die-Encounter with antigen leads to the differentiation of activated B cells into plasma cells and memory cells-plasma cells become antibody producing machines and are unreactive to antigen-some B cells go to germinal centers and undergo affinity maturation-memory cells are formed in these germinal centers-Different types of B-cell tumor reflect B cells at different stages of development- Follicular Center Cell Lymphoma- Myelomas- Others-Summary of B-Cell Population Dynamics-Summary of two main phases of B-cell development-Summary of last two main phases of B-cell development...
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This note was uploaded on 04/13/2008 for the course BIOL 445 taught by Professor Bates during the Fall '07 term at Winona.

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BIOL 445 Chapter 4 - by contact with self antigens 1....

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