2011 Practice Exam 3 - Bio2600 Introduction to Cell Biology...

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Bio2600 - Introduction to Cell Biology Name: November 29, 2011 Student ID: 1 (Version 1) Exam 3 – Version 1 Section 1: Complete each sentence with one of the answers (3 points each) 1. Nucleosomes are formed when DNA wraps _____ times around the histone octamer. A) 1.3 B) 1.7 2. Homologous chromosomes are numbered and arranged by size, from the largest to the smallest. This organized profile of a person's chromosomes is called _________. A) genotype B) karyotype 3. Several experiments were required to demonstrate how traits are inherited. _____________ obtained definitive results demonstrating that DNA is the genetic molecule? A) Griffith B) Hershey and Chase 4. Hershey and Chase showed that genes are made of DNA. The DNA in one batch of viruses is radioactively labeled with ______. A) 35 S B) 32 P 5. Sometimes chemical damage to DNA can occur just before DNA replication begins, not giving the repair system enough time to correct the error before the DNA is duplicated. This gives rise to mutation. If the adenosine in the sequence TCAT is depurinated and not repaired, which of the following is the point mutation you would observe after this segment has undergone two rounds of DNA replication? A) TCGT B) TCT 6. Beside the distortion in the DNA backbone caused by a mismatched base pair, the additional mark such as ________________________________________ is there on eucaryotic DNA to indicate the corresponding strand needs to be repaired. A) a nick in the template strand B) a nick in the new strand 7. Even though DNA polymerase has a proofreading function, it still introduces errors in the newly synthesized strand at a rate of 1 per 10 7 nucleotides. To what degree does the mismatch repair system decrease the error rate arising from DNA replication? A) 100-fold B) 1000-fold 8. In a double stranded DNA helix, ________________________. A) adenine always base pairs with guanine B) purines base pair with pyrimidines 9. _____________ are often found in clusters covalently joined together to contact the DNA bases in the major groove. A) Homeodomains B) Zinc fingers
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Bio2600 - Introduction to Cell Biology Name: November 29, 2011 Student ID: 2 (Version 1) 10. Eventually, most proteins will be degraded by a large complex of proteolytic enzymes called the __________________. A) proteasome B) lysosome 11. The __________________ enzyme catalyzes the formation of a new peptide bond between the growing polypeptide chain and the newly arriving amino acid. A) peptidyl ligase B) peptidyl transferase 12. The segments of primary RNA that are cleaved off by spliceosomes are called ________________. A) introns B) exons 13. The _________ subunit of a ribosome is the first to interact with new mRNAs. A) large B) small 14. __________________ molecules are important in the splicing of RNA transcripts. A) siRNA B) snRNA 15. Proteins that link the distantly bound transcription regulators to RNA polymerase and the general transcription factors include the large complex of proteins called the__________________. A) mediator B) activator 16. Cells can transmit information about gene expression to their progeny is through DNA __________.
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