Practice Exam 3 2012 - Bio2600 Introduction to Cell...

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Bio2600 - Introduction to Cell Biology Name: November 27, 2012 Student ID: 1 (Version 1) Exam 3 – Version 1 Section 1: Identify the single BEST answer for each question (3 points each). 1. In eucaryotes, RNA primers are made at intervals of about 200 nucleotides on the lagging strand, but are later removed by ______________ that recognize an RNA strand in an RNA/DNA helix. A) Nuclease B) Primase 2. One eucaryotic chromosome contains ________________ replication origin(s). A) single B) multiple 3. If the cytosine in the sequence TCATAT is deaminated and not repaired, which of the following is the point mutation you would observe after this segment has undergone two rounds of DNA replication? A) TTATAT B) TATAT 4. RNA in cells differs from DNA in that ___________________. A) it is single-stranded and cannot form base pairs B) it is single-stranded and can fold up into a variety of structures 5. Transcription is similar to DNA replication in that ___________________. A) nucleotide polymerization occurs only in the 5 -to-3 direction B) an RNA transcript is synthesized discontinuously and the pieces are then joined together 6. In eucaryotes, the initiator tRNA, coupled to methionine, is first loaded into the ______________ of the small ribosomal subunit, along with additional proteins called translation initiation factors. A) P-site B) A-site 7. Bacterial promoters have specific nucleotide sequences such as the conserved -10 sequence that are recognized by RNA polymerase. The -10 sequence contains _______________. A) TTGACA B) TATATT 8. Histone acetylases covalently attach an acetyl group to selected lysines in the tail of histone proteins and thereby alters chromatin structure, which has __________effects on transcription initiation. A) positive B) negative 9. The ________________, a structural motif found in many eucaryotic DNA-binding proteins, consists of three consecutive a helices. A) Homeodomain B) zinc finger motif 10. In principle, how many different cell types can an organism having five different types of transcription regulator and thousands of genes create? A) up to 16 B) up to 32
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Bio2600 - Introduction to Cell Biology Name: November 27, 2012 Student ID: 2 (Version 1) 11. During transcription in __________________ cells, transcriptional regulators that bind to DNA thousands of nucleotides away from a gene’s promoter can affect a gene’s transcription. A) procaryotic B) eucaryotic 12. Many bacterial promoters contain a region known as an __________________, to which a specific transcription regulator binds. A) operon B) operator 13. Kinesins and dyneins ____________________. A) have tails that bind to the filaments B) often move in opposite directions to each other 14. The _______________ nature of a myosin thick filament is essential for muscle contraction. A) unipolar B) bipolar 15. Cilia and flagella use _______________ motors to create movement. A) kinesin B) dynein 16. The assembly of _______________ is essential for animal cell migration. A) microtubules B) actin filaments 17. The drug colchicine ______________________.
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