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Lecture 1.pdf - Bio Core I: Molecular Systems BIOL-GA 1001...

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Bio Core I: Molecular SystemsBIOL-GA 1001David A. ScicchitanoBrown Building; Room 857das2@nyu.edu
2Course OutlineModule 1: BiomoleculesMeetings 1−5Module 2: Transcription and TranslationMeetings 6−9Module 3: Genetics, Genomics, Systems BiologyMeetings 10−14Midterm Examination 1Midterm Examination 2Final Examination
3InstructorsSuse Broyde (Module 1)Field:Computational Structure PredictionResearch:Mutagens and DNA damageDavid A Scicchitano (Modules 2 and 3)Field:Molecular Cell BiologyResearch:DNA Damage and Repair
4Tuesday 4:55-6:10 PM(EDT/EST)Room 10219 West 4th StreetTuesday, 6:20-7:35 PM(EDT/EST)Room 10219 West 4th StreetRecitations are optional but strongly encouraged.RecitationsDr. David Aristizabal Corrales
5ExamsThursday, October 7, 20215:00 – 6:00 PM (75 minutes)Exam - Module 1Thursday, November 4, 20215:00 – 6:00 PM (75 minutes)Exam - Module 2Thursday, December 16, 2021(Finals Week)6:00 – 7:50 PM (110 minutes)Exam - Module 3All examinations are mandatory!
6Calculation of Final GradesExam - Module 1Exam - Module 2Exam - Module 3Total30%35%35%100%30pt35pt35pt100pt
7Academic integrity is essential!
8Office HoursDavid A Scicchitano(das2@nyu.edu)Tuesdays 3:00 PM - 5:00 PM (EDT/EST)or by appointment.Suse Broyde([email protected])Friday 11:00 AM – 1:00 PM (EDT/EST)or by appointment.
9Textbook (optional)Lectures will be recorded and posted.Lodish, H., Berk, A., Kaiser, C. A., Krieger, M., Bretscher, A.,Ploegh, H., Martin, K. C., Yaffe, M. and Amon, A.Molecular CellBiology, 9th edition (2021) W. H. Freeman and Company, NewYork.
Introduction to MolecularBiologySeptember 2, 2021Bio Core IMeeting 110David Scicchitanodas2@nyu.edu
phenotype:the observable characteristics or traits of anorganism that are produced by the interaction of thegenotype and the environment…., June 14, 2021.genotype:an individual's collection of genes…., June 14, 2021VERSUS
12To understand phenotypes and disease, wemust define biological processes at themolecular level!AND ADDRESS THE FOLLOWINGWhat is a gene?
13The skin (epidermis) is not attached well to the underlying tissue (dermis).Gentle pulling causes blistering and peeling.There is a high risk of infection and chronic inflammation.The condition is heritable i.e. there is a mutation in the DNA).It is rare (incidence <1:1,000,000 for severe form).Dystrophic Epidermolysis Bullosa)Imagine a condition in which…(aka Butterfly Children)
14The genetic basis ofdystrophic epidermolysisbullosa(DEB) is knownCausative mutation was found by following genetic inheritance patterns.Loss of function of the gene COL7A1, which encodes collagen VII.Lack of collagen VII function weakens anchoring of the skin
There are an estimated 13,000 gene-based diseases (most of them rare).

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Term
Spring
Professor
WASHBURN
Tags
DNA, Covalent Bonds, Professor Scicchitano, Professor Broyde

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