Lecture_39 Sequence Compare

Lecture_39 Sequence Compare - ANNOUNCEMENTS Apr 28 What...

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ANNOUNCEMENTS – Apr. 28 • Next reading quiz covers Chapter 20 , due before class Fri., May 2. Chapter 25 due May 5 . • The final exam is scheduled for Thursday, May 15 at 7:30-9:30 am . Check ICON for room assignments. Poll for scheduling final review session will be delivered through Piazza. Get your own clicker out and ready. Loaners available if you need one. What difference does it make? by The Smiths
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Final Exam: Focal Areas of Integrative Questions • The Final Exam covers the last section and will also include questions that integrate the overarching themes that are central to the course. • The integrative questions will cover: § Flow of energy through living systems and the metabolic reactions (i.e., photosynthesis, glycolysis, cellular respiration) involved in energy conversions § Cell division and transmission of genetic information from parents to offspring § Structure and function of DNA; i.e., gene structure and the synthesis of a polypeptide § Organization of these processes in the eukaryotic cell
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2 4 Sequence Evolution
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Sequence Evolution: Learning Goals DNA and protein sequence alignments reveal similarities and differences between species within homologous regions Observed differences between homologous sequences provide minimal estimates of divergence The rate of neutral mutation determines the rate of neutral evolution
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Genome Evolution: Key Terms
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Genome Evolution: Learning Goals & Objectives DNA and protein sequence alignments reveal similarities and differences between species within homologous regions § Explain how insertion-deletion mutations impact the alignment of DNA and protein sequences. § Infer the number of differences from comparison of aligned sequences.
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24.1 How Are Genomes Used to Study Evolution? A homologous feature is shared by two or more species and was inherited from a common ancestor. Only about ½ of all genes exist in a single copy per haploid cell, others are members of gene families Before genes and proteins can be compared, homologous positions in the nucleotide or amino acid sequences are aligned.
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24.1 How Are Genomes Used to Study Evolution? Sequence alignment technique: Deletions and insertions in the sequence that have occurred since the two species diverged are determined by adding gaps and aligning sequences.
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