Psychosis - black box warning for atypical antipsychotics Treatment of ADR's ADR Overview Treatment EPS occurs shortly after start therapy decrease

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Psychosis and Schizophrenia Schizophrenia is a condition associated with psychosis - increased dopamine leads to symptoms of psychosis **ex: hallucinations, delusions, disorganized speech (treatable w/ meds) **ex: affective flattening, alogia, avolition, anhedonia, asociality **ex: poor concentration, memory disturbances, inability plan, poor abstraction Antipsychotics Examples MOA ADR's Typical dopamine blockade worsens neg symps - azine Low: chlorprom-, thiorid- worsens cognitive symps EPS and TD prolactin elevation Atypical sedation - pine cloza-, olanza-, quetia- - reduced EPS and TD risk weight gain - done risperi-, paliperi-, ziprasi- - reduced prolactin elevation aripiprazole - improves - symptoms clozapine reserved for treatment resistant patients
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Unformatted text preview: ** black box warning for atypical antipsychotics Treatment of ADR's ADR Overview Treatment EPS occurs shortly after start therapy decrease antipsychotic dose; switch from high to low potency switch from typical to atypical; adjuntive medication dystonia sever onset of abnormal posture benztropine diphenhydramine lorazepam pseudoparkinsonism slowed speech, resting tremor benztropine trihexyphenidyl akathisia motor restlessness B-blocker (propranolol) benzodiazepines TD involuntary abnormal movements PREVENT - reduce dose Positive Symptoms - more symtpoms Negative Symptoms - symptoms that take away from normal presentation Cognitive Symptoms - decreased cognitive functioning Benefits : improves + symptoms Mild: perphen-, loxa pine High: haloper idol , fluphen-...
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This note was uploaded on 04/07/2008 for the course PHARM 338 taught by Professor Karboski during the Fall '07 term at University of Texas at Austin.

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