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Class Lecture-Gas Exchange in the Lungs

Class Lecture-Gas Exchange in the Lungs - Gas Exchange in...

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Gas Exchange in the Lungs
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Variation of Alveolar PO 2 and PCO 2
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Variation of Capillary PO 2
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O 2 Diffusion PO 2 mixed venous blood 40 mm Hg Hb already loaded 75% with O 2 Alveolar PO 2 is 100 mm Hg Capillary Alveolar PO 2 reaches alveolar PO 2 about one third of way along the capillary
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O 2 Diffusion
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Diffusion of CO 2 Mixed venous blood entering the pulmonary capillary has a PCO 2 of ~46 mm Hg Alveolar PCO 2 is ~40 mm Hg Thus CO 2 diffuses in the opposite direction to O 2 along the capillary reaching diffusion equilibrium
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Diffusion of CO 2
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Alveolar and Arterial P CO 2 are inversely Proportional to Alveolar Ventilation
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Alv. and Arterial PCO 2 are inversely Proportional to Alveolar Ventilation
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Alv. and Arterial PCO 2 are inversely Proportional to Alveolar Ventilation One of the most important concepts in respiratory physiology Other things being equal, Alveolar P CO2 is inversely proportional to alveolar ventilation If CO 2 production is fixed, then doubling of V A causes PA CO2 to fall to half its value, conversely, halving of V A causes PACO2 to double
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Alv. and Arterial PCO 2 are inversely Proportional to Alveolar Ventilation As Arterial PCO 2 is virtually the same as Alveolar PCO 2 Changes in V A affect P ACO2 and PaCO 2
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Alv. and Arterial PCO 2 are inversely Proportional to Alveolar Ventilation
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Alveolar and Arterial PO 2 Rise with increased Alveolar Ventilation Increases in alveolar ventilation cause alveolar P O 2 to rise and at an infinite V A approach the inspired P O 2 of 149 mm Hg
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Alveolar and Arterial PO 2 Rise with increased Alveolar Ventilation This has a different relationship to PA CO2 (which essentialy starts at 0 mm Hg) PA O2 depends critically on V A , but is also influenced by other gases (H 2 O, CO 2 )
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Lung III Wednesday II Gas Exchange Dr. Gordon MacGregor Lecture
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