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Class Lecture-Lung I - Lecture Lung I Dr Gordon MacGregor...

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Lung I Dr. Gordon MacGregor Lecture
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Human Lung 2 lobes on left 3 lobes on right
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What stops alveolus collapsing?
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Surface Tension of Alveoli Alveoli are lined with film of fluid Surface Tension Attractive forces between adjacent molecules of liquid are stronger than attractive forces between molecules of liquid and molecules of gas As molecules of liquid are drawn together by attractive forces, surface area becomes smaller Surface tension generates a pressure that tends to collapse alveolus: P = 2T/r
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Surface Tension of Alveoli P = 2T/r Large alveolus has low collapsing pressure Small alveolus has high collapsing pressure However, alveoli need to be small to increase total surface area for gas exchange Fundamental conflict is solved by Surfactant
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Surfactant Mixture of phospholipids that line alveoli and reduce their surface tension Reduces collapsing pressure for a given radius Intermolecular forces between surfactant molecules break up the attracting forces between liquid molecules lining the alveoli Surfactant also increases lung compliance Reduces work of expanding the lungs during inspiration
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Surfactant
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