sicklecellanemia

sicklecellanemia - Jeong 1 Susanna Jeong Professor Henry M....

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Susanna Jeong Professor Henry M. McHenry Amy Porter Anthropology 1 24 October 2007 Sickle-Cell Anemia Outline 1) Introduction a) Basic introductory information regarding sickle-cell anemia b) Basic introduction of the topic of the paper, heterozygous advantage c) Thesis i) This paper will carefully analyze the importance of the monogenic trait, sickle-cell anemia, its process of evolution, and allelic frequencies in specific biospheres to increase the understanding of human evolutionary biology. 2) The reason why natural selection has not purged sickle-cell anemia a) Reason being that sickle-cell carriers have resistance against malaria b) When sickle-cell anemia became a heterozygous advantage against malaria 3) Malaria a) Definition of malaria and how it is contracted b) Why heterozygotes are resistant to malaria and how it works 4) The structure and creation of sickle-cell anemia through point mutation Jeong 1
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a) Point mutation i) Substitution of valine instead of the normally present glutamic acid b) Autosomal Co-dominance c) The three type of phenotypic and genotypic expressions i) HbA HbA ii) HbA HbS iii) HbS HbS 5) Where sickle-cell anemia has the highest allelic frequency. a) Western and central Africa b) Allelic frequencies i) Of normal homozygotes ii) Of heterozygote carriers iii) Of affected homozygotes 6) The allelic frequency of sickle-cell anemia in a population where malaria had once been prevalent, but now had been eradicated. a) Genetic drift 7) Conclusion Jeong 2
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Sickle-Cell Anemia Sickle-cell anemia is a fatal hemoglobin disorder in which people rarely live past the age of twenty. Despite its inherent destructive nature to the human body, natural selection has increased the allelic frequency in populations where malaria is present. This is because heterozygotes with the sickle-cell trait are resistant to malaria and have a higher percentage of reproductive success in those populations where malaria is prevalent. The correlation between malaria and the sickle- cell anemia is direct evidence that natural selection is the force of evolution, as stated in Charles Darwin’s On the Origin of Species (Jurmain, 2008:28). This paper will carefully analyze the importance of the monogenic trait, sickle-cell anemia, its process of evolution, and allelic frequencies in specific biospheres to increase the understanding of human evolutionary biology. Through scientific research, it has been concluded that the reason for the present existence
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This note was uploaded on 04/13/2008 for the course ANT 001 taught by Professor Mchenry during the Fall '08 term at UC Davis.

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sicklecellanemia - Jeong 1 Susanna Jeong Professor Henry M....

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