Lecture 17 - Monday October 2 2006 Lecture 17 Announcements...

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Monday, October 2, 2006, Lecture 17 Announcements: 1. Reading and problem assignments for this week, as in LG 2. RasMol assignment # 6, Chymotrypsin. This is the one and only RasMol assignment that will appear on the midterm exam. Note: no office hrs or reviews for this RasMol until Sun 10/15! 3. Conflict for the midterm exam Th 10/19 7:30PM? Meet briefly after class on Wed 10/4 to set the day and time. Day will probably be Fri 10/20 or Sat 10/21. 4. Reminder of quiz return policy: any quizzes not picked up at the time they are returned in class will be brought to the Reserve Desk of the Bio Center. This includes regraded quizzes, which are normally placed in the folders for return along with the quizzes from that week. 5. Cornell extern program—shadow alumni in their workplace. Check out specific opportunities at career.cornell.edu or the notebooks in the Career Center. Meetings to discuss externships in HEC Auditorium 10/4 or 10/16 from 5 – 6:15PM. Friday's lecture: Michaelis-Menten Equation allows rxn rate info, and some binding affinity info, from simple measurements of [S] and V Each elementary rate constant is associatted with one free energy barrier How to show a catalyzed rxn on a diagram of G o vs “progress of rxn” Using the Lineweaver-Burk plot Today's lecture: Look next at chymotrypsin, further down the table on page 115. It has a turnover number of 100 sec -1 . Hey, not very fast, is it?! Now it might seem that chymotrypsin is not as efficient an enzyme -- that carbonic anhydrase is a better, faster catalyst than chymotrypsin, by a factor of about 6000. Now we come to an important principle when comparing enzyme efficiency : First look at the uncatalyzed reactions , and compare these reactions to the catalyzed reactions: p. 116 The un catalyzed reaction of CO 2 reacting with water to form the products HCO 3 - + H + , has a forward rate constant k 1 of about 10 -1 sec -1 . So this is a rather fast reaction, even uncatalyzed!
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