Lecture 9 - Lecture 9 ANNOUNCEMENTS 1 Meet with any...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 9, September 13, 2006 ANNOUNCEMENTS: 1. Meet with any interested students on Friday 9/15, 1:25– 2:15PM in Comstock B106 to discuss: “Should I apply to medical school this year? Should I apply at all!? Help!” 2. The Sunday 1 - 3 PM Rasmol review sessions in Carpenter Hall are now in the Red Room , just down the hall from the Orange. 3. Meet reps of many many grad and professional schools: Wed 9/27 Barton Hall, 11AM – 2:30PM 4. Regraded quizzes—how to get them back?! Handed in by a Wed, should be returned on that Friday along with the quiz of that week. (After, they go to the Bio Center in Stimson). Monday's lecture : Multidomain proteins (within one polypeptide chain) are common. IV structure is common. It is based upon good steric & "chemical fit" of protein surfaces. IV structure can be stable, e.g. hemoglobin, or transient, e.g. the insulin signaling complex. Thermodynamic way of looking at protein stability (folding vs unfolding) Today's lecture: First, the prof wants to clarify a word that is commonly used, but which has "jargon" usage in biochemistry: What is the meaning of "reversible" ? e.g. Mb + O 2 MbO 2 "Reversible binding" means: 2. Appreciable concentrations of both reactants and products are present at equilibrium, i.e. the rxn does not go extremely far to the left or right Oh no! multiple meanings! 1. Forward and reverse rxns occur multiple times during the observation 3. Not covalent binding
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
p. 71 We can represent the relationship between the Gibbs Function and the protein structure on a graph. We use the standard state, G o , because the pressure is fixed at 1 atm and because we want concentration to be fixed : G depends on concentration, and we do not want to complicate our discussion now with this dependence. More on conc dependence of G later in the course. e The x-axis is termed "structural coordinates". What does that mean?! This is merely a crude way to indicate different structures, with close distance on this axis indicating close in structure . (There is no precise way to use one axis of a graph to indicate all the possible protein structures!).
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern