Lecture 8 Neurophysiology (2).pdf - Lecture 8...

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Anatomy & Physiology I 2021 Kathleen M. Kayes-Wandover, Ph.D.Page 1Lecture 8NeurophysiologyGeneration of the Action Potential and Information ProcessingObjectives: Following completion of this material, the student should be able to:1.Explain the creation and maintenance of the resting membrane potential.2.Describe the events involved in the generation and propagation of an action potential.3.Describe the structure of a cholinergic synapse, and explain the mechanism involved in synaptic activity.4.Discuss the interactions that enable information processing to occur in neural tissue.I.OverviewA.The neurons of the nervous system conduct electrical impulses, or signals, are a means of communication (betweensensory receptors, muscles and glands, and the brain and spinal cord).B.Important processes involved:1.Resting membrane potentiala.Communication always begins with a change in the RMP2.Graded potentialsa.Temporary changes in RMP result in what are called graded potentials.If it is large enough, anaction potential is triggered.3.Action potentialsa.These will be propagated along the axon to another synapse.4.Synaptic activitya.These electrical signals must travel along the axon of the neuron and cross thesynapseto effectchange from neuron to neuron.b.A neuron affects other neurons by releasing a neurotransmitter that binds to chemical receptors.5.Information processinga.The response of the postsynaptic cell depends upon the type of receptorthat is activated and otherstimuli that are influencing the cell.II.Membrane PotentialA.Principles of Electricity1.Opposite charges attract, and energy must be used to separate them; when opposite charges come together,energy is liberateda.Therefore, separated electrical charges have potential energyb.Measure of potential energy =______________________2.Voltage is always measured between two points and is called the_________________________________orpotential between the two points.3.Flow of electrical charge from one point to another is called___________________________a.The amount of charge moving between two points depends on voltage andresistance(hindering offlow of charge)b.Ohm's law states that __________________________________________________
Anatomy & Physiology I 2021 Kathleen M. Kayes-Wandover, Ph.D.Page 24.Current is proportional to ________________________________________ and is inversely proportional to__________________________________________.5._____________________________________ are ionic solutions.Voltage is related to _________________________________________Resistance is provided by the ________________________________________B.Resting Membrane Potential (Refer to picture from lecture 2)1.A resting neuron's cell membrane is said to bepolarized=electrically charged(i.e. the charge inside the cellis different than the charge outside).a.Consequently, a potential difference (PD) exists across this resting cell membrane.i.the difference in electrical charge between 2 points (i.e. across a cell membrane).ii.The RMP of a nerve cell is measured to be-70 mV.

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Kathleen M Kayes Wandover

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