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bioenergetics_2-2007

bioenergetics_2-2007 - Bioenergetics 2 Goals Review...

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Bioenergetics 2 Goals: Review glycolysis, TCA, and e - transport Fat (lipid) utilization during exercise Protein utilization during exercise Describe the cross-over concept:
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Recall: ATP is an energetic intermediate
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2 molecules of GADPH Glycolysis – detailed view Anaerobic pathways of ATP production
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The complete breakdown of glucose via glycolysis and the TCA cycle can be written as: C 6 H 12 O 6 + 6O 2 6CO 2 + 6H 2 0 This is fundamentally an exergonic process and yields free energy ( E = 686 kcal/mole glucose) Recall: rephosphorylation of ADP ATP requires 7.3 kcal per mole. Therefore: 686/7.3 = 94 moles (or molecules) of ATP. How many molecules of ATP are produced from the complete oxidation of glucose? Why the discrepancy?
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Fat as a fuel substrate during exercise: Reminder: Fats stored as triglycerides FFA’s used during exercise Benefits of fat as a fuel substrate; Fat is an almost inexhaustible fuel source compared to carbohydrate High energy for weight. Fat has 9 kcal/gram versus about 4 kcal/gram for carbohydrate Fat utilization spares muscle glycogen
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Downside of fats as a fuel substrate Lipid utilization is slow, and proceeds at rates much slower than carbohydrate utilization Fat catabolism proceeds only as an aerobic process. Lipid utilization is metabolically “costly” there are more steps more oxygen is necessary to oxidize lipid versus carbohydrate.
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How fast are carbohydrate reserves depleted during exercise?
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