Practice Quiz on Correct Folding of Proteins

Practice Quiz on Correct Folding of Proteins - 1...

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1 The correct folding of proteins is necessary to maintain healthy cells and tissues.  Unfolded proteins are responsible for such neurodegenerative disorders as  Alzheimer’s, Huntington’s, and Creutzfeld–Jacob disease (the specific faulty  protein is different for each disease). What is the ultimate fate of these disease- causing, unfolded proteins? (a) They are degraded. (b) They bind a different target protein. (c) They form structured filaments. (d) They form protein aggregates. 2 The three-dimensional coordinates of atoms within a folded protein are  determined experimentally. After researchers obtain a protein’s structural details,  they can use different techniques to highlight particular aspects of the structure. 
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Unformatted text preview: What visual model best displays a protein’s secondary structures ( helices and α sheets)? β (a) ribbon (b) space-filling (c) backbone (d) wire 3 Typical folded proteins have a stability ranging from 7 to 15 kcal/mol at 37°C. Stability is a measure of the equilibrium between the folded (F) and unfolded (U) forms of the protein, with the unfolded form having a greater free energy. See Figure Q4-10: for a protein with a stability of 7.1 kcal/mol, calculate the fraction of protein that would be unfolded at equilibrium at 37°C. The equilibrium constant ( K eq ) is related to the free energy (D G °) by the equation K eq = 10 –D G °/1.42 . Figure Q4-10...
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  • Summer '12
  • yang
  • tissues.  Unfolded proteins, different target protein

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