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Polycyclic Armoatic Hydrocarbons

Polycyclic Armoatic Hydrocarbons - turn PAHs into reactive...

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CHEM 2380.001 October 9, 2007 Polycyclic Aromatic Hydrocarbons (PAHs) There are approximately 10,000 compounds composed of 100 different chemicals that are classified as PAHs. PAHs are formed during the incomplete burning of carbon containing compounds (tobacco, meat, coal, oil, gas, etc.) Some PAHs are manufactured for use in the production of dyes, plastics, pesticides, etc. Exposure to PAHs usually occurs by breathing air contaminated with wild fire smoke/residue or coal tar, by eating foods that have been grilled, and by smoking or second hand smoking (Agency for Toxic Substances and Disease Registry). In mice, high levels of PAH exposure decreased the likelihood of reproducing; if they were able to reproduce, their offspring had higher levels of birth defects and lower birth weights. PAHs only become toxic after they’ve been activated by a special type of metabolizing enzyme—the main two enzymes responsible for activating PAHs are CYP1A1 and CYP1B1; they turn the PAHs into epoxide intermediates that are converted into diol-eopoxides, in other words, they
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Unformatted text preview: turn PAHs into reactive electrophiles that initiate cell transformation (cause cancer). This is sort of bad news for me because I enjoy grilled meats more than just about anything else; I’m also around second hand smoke more than I’d like to be; now I have an excuse to excuse myself – “I hate to leave, but the PAHs that I’m being exposed to from your cigarette smoke are going to kill both of us.” References: Agency for Toxic Substances & Disease Registry. Poly Aromatic Hydrocarbons, PAHs ToxFAQs. http://www.atsdr.cdc.gov/tfacts69.html . October 9, 2007. Department of Health & Family Services. Polycyclic Aromatic Hydrocarbons (PAHs). http://dsfs.wisconsin.gov/eh/ChemFS/fs/PAH.htm Shimada, T, Fuji-Kuriyama, Y. Cancer Science . “Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1.” Jan 2004. Volume 95. Page 1....
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