BIOL 445 Chapter 7 part two

BIOL 445 Chapter 7 part two - Chapter 7 (cont.) -...

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Chapter 7 (cont.) - Complement Complement tags microorganisms for destruction
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The complement system is activated by evidence of infection Three pathways lead to complement activation All three pathways ultimately lead to binding of C3b to the pathogen surface Soluble components are synthesized in the liver in the enzymatically inactive form known as zymogens Complement components were named as they were discovered, not in order that they are activated
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The classical pathway of complement activation tags antigens that have been bound by antibodies 1 molecule of IgM or two of IgG are bound to bacterial cell surface
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C1 binds to the antibody(s) by the c1q portion This activates C1r to cleave C1s
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Activated C1s cleaves C4 to C4a and C4b, C4b binds to the bacteria cell surface Activated C1s also cleaves C2 into C2a and C2b. C2a binds to C4b C4b2a is an active C3 convertase, cleaving up to a thousand of C3 molecules to C3a and C3b
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C3b binds to the microbial surface as well as to C4b2a to form C4b2a3b C4b2a3b is a powerful C5 convertase. C5 is cleaved into C5a and C5b.
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This note was uploaded on 04/14/2008 for the course BIOL 445 taught by Professor Bates during the Fall '07 term at Winona.

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BIOL 445 Chapter 7 part two - Chapter 7 (cont.) -...

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