106L06_Notes - Introduction Introduction to Neuroscience...

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1 Introduction to Neuroscience Lecture 6: Synaptic Transmission Reading Assignment: Bear et al., Chapter 5. CBNS 106 2 Introduction • Synaptic Transmission – The process of information transfer at a synapse – Plays role in all the operations of the nervous system – 1897: Charles Sherrington- “synapse” – Chemical and electrical synapses • 1921- Otto Loewi • 1959- Furshpan and Potter CBNS 106 3 Types of Synapses • Direction of Information Flow – In one direction: Neuron to target cell – First neuron = Presynaptic neuron – Target cell = Postsynaptic neuron CBNS 106 4 • Electrical Synapses – Gap junction • Channel – Connexon- formed by six connexins – Cells are said to be “electrically coupled” • Flow of ions from cytoplasm to cytoplasm Types of Synapses
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2 CBNS 106 5 Types of Synapses • Electrical Synapses (Cont’d) – Very fast transmission • Postsynaptic potentials (PSPs) – Synaptic integration: Several PSPs occurring simultaneously to excite a neuron (i.e. causes AP) CBNS 106 6 Types of Synapses • Chemical Synapses CBNS 106 7 • CNS Synapses (Examples) – Axodendritic: Axon to dendrite – Axosomatic: Axon to cell body – Axoaxonic: Axon to axon – Dendrodendritic: Dendrite to dendrite – Gray’s Type I: Asymmetrical, excitatory – Gray’s Type II: Symmetrical, inhibitory Types of Synapses CBNS 106 8 • The Neuromuscular Junction (NMJ) – Studies of NMJ established principles of synaptic transmission – High clinical relevance Types of Synapses
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3 CBNS 106 9 Principles of Chemical Synaptic Transmission • Basic Steps – Neurotransmitter synthesis – Load neurotransmitter into synaptic vesicles – Vesicles fuse to presynaptic terminal – Neurotransmitter spills into synaptic cleft – Binds to postsynaptic receptors – Biochemical/Electrical response elicited in postsynaptic cell – Removal of neurotransmitter from synaptic cleft CBNS 106
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This note was uploaded on 04/15/2008 for the course CBNS 106 taught by Professor Korzus during the Winter '08 term at UC Riverside.

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106L06_Notes - Introduction Introduction to Neuroscience...

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