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Unformatted text preview: Problem set for lecture 6: Synaptic Transmission Reading Assignment: Bear et al. Chapter 5. C. Questions - Test_06: 1. Quantal analysis shows that a single action potential at the neuromuscular junction causes an EPSP of 40 mV or more as against only a few tenths of a millivolt at many CNS synapses. What accounts for this difference? Choose the correct option. A) A larger number of synaptic vesicles releasing neurotransmitter at the neuromuscular junction compared with CNS synapses B) A larger number of transmitter molecules within the synaptic vesicles of a motor neuron compared with CNS synapses C) Larger receptors at the neuromuscular junction compared with CNS synapses D) A larger synaptic cleft at neuromuscular junction compared with CNS synapses 2. What are transporters? What is their role? Choose the correct option. A) Enzymes that synthesize neurotransmitters from metabolic precursors; responsible for concentrating neurotransmitters in the synaptic cleft B) Synthesizing enzymes for both amino acid and amine neurotransmitters; responsible for concentrating neurotransmitters inside the vesicle C) Special proteins embedded in the vesicle membrane; responsible for synthesizing neurotransmitters D) Special proteins embedded in the vesicle membrane; responsible for concentrating neurotransmitters inside the vesicle 3. What is a gap junction? Choose the correct option. A) Synapse between a neuron and a muscle cell B) Electrical synapse C) Synapse between a neuron and a glandular cell D) Chemical synapse 4. Opening of the chloride channel allows Cl ions to cross the membrane, bringing the membrane potential toward the ___________equilibrium potential, ECl, about 65 mV. If the membrane potential was less negative than 65 mV when the transmitter was released, the activation of these channels would cause a ___________________IPSP. A) True B) False 5. What is the other name for dense-core vesicles? Choose the correct option. A) Secretory granules B) Synaptic cleft C) Presynaptic element D) Synaptic vesicles 6. How do nerve gases interfere with synaptic transmission at the neuromuscular junction? Choose the correct option. A) By blocking transmitter-gated ion channels at neuromuscular junction B) By inhibiting the enzyme AChE C) By increasing the availability of AChE D) By exhausting the number of synaptic vesicles in the synaptic terminal 7. Under what conditions are peptide neurotransmitters released from the synaptic terminal? Choose the correct option. A) Every action potential B) Only in 1 in 100 action potentials C) Only with high-frequency trains of action potentials D) Only with low-frequency trains of action potentials 8. What are second messengers? Choose the correct option....
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- Winter '08