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Test_14_Qs - How would you determine whether GABA or Gly or...

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Lecture 13. Neurotransmitter Systems Review questions 1 of 1 Lecture 13. Neurotransmitter Systems Question 1: If you could place microelectrodes into both a presynaptic and a postsynaptic neuron, how would you determine whether the synapse between them was chemically or electrically mediated? Question 2: List the criteria that are used to determine whether a chemical serves as a neurotransmitter. What are the various experimental strategies you could use to show that ACh fulfills the criteria of a neurotransmitter at the neuromuscular junction? Question 3: What are three methods that could be used to show that a neurotransmitter receptor is synthesized or localized in a particular neuron? Question 4: Compare and contrast the properties of (a) AMPA and NMDA receptors, and (b) GABAA and GABAB receptors. Question 5: Synaptic inhibition is an important feature of the circuitry in the cerebral cortex.
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Unformatted text preview: How would you determine whether GABA or Gly, or both, or neither, is the inhibitory neurotransmitter of the cortex? Question 6: Glutamate activates a number of different metabotropic receptors. The consequence of activating one subtype is the inhibition of cAMP formation. A consequence of activating a second subtype is activation of protein kinase C. Propose mechanisms for these different effects. Question 7: Do convergence and divergence of neurotransmitter effects occur in single neurons? Question 8: Ca2+ ions are considered to be second messengers. Why? Question 9: How do the diffuse modulatory and point-to-point synaptic communication systems in the brain differ? List four ways. Question 10: Under what behavioral conditions are the noradrenergic neurons of the locus coeruleus active? The noradrenergic neurons of the ANS?...
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