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106L03_slides - Introduction to Neuroscience Lecture 3...

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1 Introduction to Neuroscience Lecture 3: The Neuronal Membrane at Rest Introduction Action potential in the nervous system – Action potential vs. resting potential The Cast of Chemicals • Cytosolic and Extracellular Fluid – Water • Key ingredient in intracellular and extracellular fluid • Key feature – uneven charge The Cast of Chemicals Cytosolic and Extracellular Fluid (Cont’d) – Ions: Atoms or molecules with a net electrical charge Spheres of hydration
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2 The Cast of Chemicals The Phospholipid Membrane – Hydrophilic • Dissolve in water due to uneven electrical charge (e.g., salt) – Hydrophobic • Does not dissolve in water due to even electrical charge (e.g., oil) – Lipids are hydrophobic • Contribute to resting and action potentials The Cast of Chemicals • The Phospholipid Membrane –The Phospholipid Bilayer The Cast of Chemicals • Protein – Molecules • Enzymes • Cytoskeleton • Receptors Special transmembrane proteins – Control resting and action potentials The Cast of Chemicals • Protein – Structure Amino acids Concept of alpha carbon and R groups
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3 The Cast of Chemicals • Protein – Structure (Cont’d) Peptide bonds and polypeptides
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