106L17_Notes - Introduction to Neuroscience Lecture 17...

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•1 Introduction to Neuroscience Lecture 17: Synaptic plasticity Reading Assignment: Bear et al., Ch. 24 (pp. 776 - 786) CBNS 106 2 Vertebrate Models of Learning • Neural basis of memory: Learning and memory can result from modifications of synaptic transmission Synaptic modifications can be triggered by conversion of neural activity into intracellular second messengers Memories can result from alterations in existing synaptic proteins
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•2 CBNS 106 3 Vertebrate Models of Learning • Synaptic Plasticity in the Hippocampus – LTP and LTD • Key to forming declarative memories in the brain – Bliss and Lomo • High frequency electrical stimulation of excitatory pathway – Anatomy of Hippocampus • Brain slice preparation: Study of LTD and LTP CBNS 106 4 Anatomy of the Hippocampus (rat) Connectivity within the hippocampal slice: EC-DG-CA3-CA1 Two layers: - Dentate Gyrus - Ammnon’s Horn (CA)
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•3 CBNS 106 5 Synaptic Plasticity in the Hippocampus LTP in CA1 CBNS 106 6 Vertebrate Models of Learning • Synaptic Plasticity in the Hippocampus: – Mechanisms of LTP in CA1 • Glutamate receptors mediate excitatory synaptic transmission – NMDARs and AMPARs
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•4 CBNS 106 7 Neuronal activity induces LTP and gene expression Ca 2+ Na + NMDAR AMPAR Post-synaptic depolarization NUCLEUS Mg 2+ CamKII Pre-synaptic neurotransmitter release Post-synaptic neuron Induction of intracellular signaling Ca 2+ CBNS 106 8 Synaptic Plasticity in the Hippocampus LTP in CA1
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This note was uploaded on 04/15/2008 for the course CBNS 106 taught by Professor Korzus during the Winter '08 term at UC Riverside.

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106L17_Notes - Introduction to Neuroscience Lecture 17...

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