BIOL 225 Chapter 35 - badfish_clicker_Au

BIOL 225 Chapter 35 - badfish_clicker_Au - Bad Fish Kristi...

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Bad Fish Kristi Hannam, SUNY-Geneseo Adapted from a case by James A. Hewlett
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2 One evening during a trip to Indonesia to study the recent sightings of a coelacanth, Dr. Marshall Westwood from the Montana Technical Institute ate a meal of pufferfish. Local Cuisine
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3 Within an hour of returning to his hotel room, he: felt numbness in his lips and tongue which quickly spread to his face and neck. began to feel pains in his stomach and throat which produced feelings of nausea and eventually severe vomiting.
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Dr. Westwood called a local hospital. Numbness in his lips and face made it almost impossible for him to communicate, but the hospital staff sent an ambulance. 4
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5 As Dr. Westwood was rushed to the hospital, he had: trouble breathing; signs of paralysis in his upper body and arms.
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6 The Physicians… kept his airway open. administered drugs to bring his heart back to a normal rhythm. put a mixture of charcoal into his stomach to help absorb any chemicals that might still be there.
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Within a few hours, Dr. Westwood's condition improved and he was on his way to a full recovery. 7 After discussing his case with his physician, he learned that he had probably been the victim of a pufferfish poisoning.
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8 POISONED! The active toxin in the tissues of this fish is a chemical called tetrodotoxin. Tetrodotoxin is a neurotoxin - it affects nerve cells (neurons). Specifically, tetrodotoxin blocks voltage-gated sodium ion channels.
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9 CQ#1: The symptoms Dr. Westwood suffered included all of the following EXCEPT: A. Fever and chills B. Numbness C. Paralysis D. Difficulty breathing E. Nausea and vomiting
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10 CQ#2: According to what you know so far, voltage-gated sodium ion channels are found in: A. Cells of pufferfish B. All living cells C. Epithelial cells D. Nerve cells E. None of the above
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11 CQ#3: If tetrodotoxin (TXX) blocks voltage-gated sodium ion channels, which part of the action potential graph would be impacted? A. Part A B. Part B C. Part C D. Part D E. Part E TIME Membrane Voltage (mV) -70 -55 0 30 A B C D E
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12 The Charge Across Cell Membranes All cells have an electrical potential difference across their plasma membrane. Called a MEMBRANE POTENTIAL The cell’s inside is negative relative to the outside. Sodium (Na+) potassium (K+) and large anions (A-) are important in maintaining the membrane potential. Extracellular Intracellular Neuron Cell Membrane Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ A- A- A- A- A- A- A- A- A- A- A- A- A- A- A- A- A-
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13 The Charge Across Cell Membranes The interior of a cell’s membrane is hydrophobic and repels ions and molecules with charge. In order for an ion to cross the membrane, it must use a channel that facilitates its movement.
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