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Unformatted text preview: Drugs by Mouth: 3 Phases 1) Pharmaceutic disintegration & dissolution 2) Pharmacokinetic 3) Pharmacodynamic NO Pharmaceutic phase if administered parenterally by: subcutaneous (Sub Q)- fewer blood vessels; slower absorbtion intramuscular (IM)- more blood vessels intravenous- 100% bioavailability 1) Pharmaceutic Phase-a drug in solid form must disintegrate into small particles to dissolve into a liquid (dissolution) excipients- fillers and inert substances that are used to allow the drug to take on a particular size & shape and to enhance drug dissolution disintegration- the breakdown of a tablet into smaller particles. dissolution- the dissolving of the smaller particles in the GI fluid before absorption rate limiting- the time it takes the drug to disintegrate and dissolve to become available for the body to absorb it Enteric-coated drugs &#2; resist disintegration in the gastric acid of the stomach...
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- Spring '08