BIPN100handout3

BIPN100handout3 - BIPN 100 Fortes Handout 3 Weihao Zheng...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
BIPN 100 – Fortes Weihao Zheng Handout 3 whzheng@ucsd.edu OH: Tuesday 6:30-7:30pm @ CLICS first floor HANDOUT # 3: Postsynaptic Receptors, NT’s and CNS Anatomy I. Neurotransmitters / Receptors a. Degradation, Diffusion, and Reuptake i. Degradation 1. Acetylcholinesterase (AChE) breaks down ACh in synaptic cleft to choline and acetate 2. Monoamino oxidase (MAO) NE, E, Serotonin, and Dopamine removal in presynaptic terminal 3. Catechol o-methyl transferase (COMT) E removal in tissue ii. Diffusion (10~20%) iii. Reuptake 1. Choline uptake (Na + /Choline symport) choline + acetate inside pre-synaptic cell gets recycled back to ACh 2. NE uptake (Na + /NE symport) repackaged into vesicles by vesicle monoamine transporter (V MAT ) 3. Serotonin uptake (Na + /Serotonin symport) a. SSRI (selective serotonin reuptake inhibitor is used for treatment of depression b. What is the difference between temporal and spatial summation? (Fig 8.27) i. Temporal summation ii. Spatial summation 1. If a postsynaptic neuron has a V rest of -70mV and V threshold of -50mV, will an AP be fired if 3 converging neurons produce EPSP of 10mV each, and 3 neurons produce IPSPs of 3mV? Why? II. Neurotransmitters Function and Location NT Type Receptor Locations Effects Agonists/Antagonists Chemical Acetylcholine (ACh) nAChR (Ionotropic) Skeletal muscles, ANS, CNS Excitatory: Opens Na+/K+ channel Muscle contraction, interneuron signaling Agonist - Nicotine Antagonist – Curare Bungarotoxin mAChR (metabotropic) Smooth/cardiac muscle, glands (Parasympathetic Input) CNS Inhibitory: Heart Excitatory: Glands, GI, bladder, bronchioles (via vagus nerves) Antagonist - Atropine Amines Norepinephrine (NE) & Epinephrine (E) Adrenergic α-1 (NE > E) (metabotropic)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 4

BIPN100handout3 - BIPN 100 Fortes Handout 3 Weihao Zheng...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online