BIPN100handout3 - BIPN 100 Fortes Handout 3 Weihao Zheng...

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BIPN 100 – Fortes Weihao Zheng Handout 3 OH: Tuesday 6:30-7:30pm @ CLICS first floor HANDOUT # 3: Postsynaptic Receptors, NT’s and CNS Anatomy I. Neurotransmitters / Receptors a. Degradation, Diffusion, and Reuptake i. Degradation 1. Acetylcholinesterase (AChE) breaks down ACh in synaptic cleft to choline and acetate 2. Monoamino oxidase (MAO) NE, E, Serotonin, and Dopamine removal in presynaptic terminal 3. Catechol o-methyl transferase (COMT) E removal in tissue ii. Diffusion (10~20%) iii. Reuptake 1. Choline uptake (Na + /Choline symport) choline + acetate inside pre-synaptic cell gets recycled back to ACh 2. NE uptake (Na + /NE symport) repackaged into vesicles by vesicle monoamine transporter (V MAT ) 3. Serotonin uptake (Na + /Serotonin symport) a. SSRI (selective serotonin reuptake inhibitor is used for treatment of depression b. What is the difference between temporal and spatial summation? (Fig 8.27) i. Temporal summation ii. Spatial summation 1. If a postsynaptic neuron has a V rest of -70mV and V threshold of -50mV, will an AP be fired if 3 converging neurons produce EPSP of 10mV each, and 3 neurons produce IPSPs of 3mV? Why? II. Neurotransmitters Function and Location NT Type Receptor Locations Effects Agonists/Antagonists Chemical Acetylcholine (ACh) nAChR (Ionotropic) Skeletal muscles, ANS, CNS Excitatory: Opens Na+/K+ channel Muscle contraction, interneuron signaling Agonist - Nicotine Antagonist – Curare Bungarotoxin mAChR (metabotropic) Smooth/cardiac muscle, glands (Parasympathetic Input) CNS Inhibitory: Heart Excitatory: Glands, GI, bladder, bronchioles (via vagus nerves) Antagonist - Atropine Amines Norepinephrine (NE) & Epinephrine (E) Adrenergic α-1 (NE > E) (metabotropic)
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BIPN100handout3 - BIPN 100 Fortes Handout 3 Weihao Zheng...

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