BIPN100handout12

BIPN100handout12 - BIPN100 Winter 2008 Dr. Fortes Ann Shih...

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BIPN100 Winter 2008 Dr. Fortes Ann Shih yushih@ucsd.edu OH: Mon 10-11 @ Roma Cafe 1. Diffusion The movement of molecules from an area of higher concentration to an area of lower concentration Q: What are the 2 factors needed in order for diffusion to take place? Hint: Fick’s Law of diffusion: Flux = ΔC x Area x Permeability, for a certain particle Permeability = lipid solubility/ (molecular size x viscosity x thickness of membrane) What is it? Examples Simple Diffusion diffusion directly across the phospholipid bilayer of a cell Facilitated Diffusion Glucose (GLUT transporters), a.a. Transport protein is solute/substrate- specific Active Transport Primary Na+-K+-ATPase = 3 Na+ in, 2K+ out. (Fig. 5-24) Ca++-ATPase H+-K+-ATPase Secondary Na+/Glu symporter Non-diffusable ions like proteins (anions), nucleotides, and K+ 2. Ion channels Channel Type What’s unique about it? Example Leak Aquaporins K + leak channel (for Vrest) ligand-gated Ach with Na + channel voltage-gated
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BIPN100handout12 - BIPN100 Winter 2008 Dr. Fortes Ann Shih...

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