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BIPN100midterm1 - BIPN 100 Mammalian Physiology 1 Name A 45...

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Unformatted text preview: BIPN 100, Mammalian Physiology 1 Name: A 45 male Kg}: Winter, 2008 _ 1St Midterm Exam ID. #: February 1, 2008 Page 1 1. (18 points). You are testing the effect of the drug digoxin, an inhibitor of Na/K pumps, on an axon. A. Write the reaction catalyzed by Na/K pumps, including all the substrates, products, and their stoichiometries: + . ' _ .4. . _ [.12 (Ba/Vat;M +2KZU+ +W+l120v~> 3&OU7L l—ZK‘W +4Ll0+Pg a t“ ”f 93:1 B. Before addition of digoxin the resting membrane potential is ~70 mV and a single stimulus Ni “0. generates a normal action potential. Predict what will happen to the resting potential (depolarized, hyperpolarized, or no change) and to the response when you give.a single stimulus immediately after adding a maximum dose of digoxin (increased or decreased ampl’ljide of spike, or no change, or no response) and briefly explain why: - . . . Resting potential: '71 0 (11471 3 because low lad/l5 Cd? 5 )Dw LL no! Hie mmwa‘h aim/$5 are W W W Action potential: ’l’lo giver/136 ,. 56,91,056 #:ij/V/ezj émafi ’Vtw‘clmr 074 [W W Wim kw? Casi/m4 [7046“ w// [not C/tmje §Ijmfazcuwj C. You continue to stimulate the axon for a few hours, go to lunch, and repeat measurements as above. . Pa Predict the results and briefly explain why: (a Resting potential: the oldri ed because, K+zeea£€xf M M cleared/rd wild} “r590." 7%? lglfimsci/W Alli/ill {A fie Mai/vi JeJéJMIMc/uaéaf‘aa MM 14/ {WW7 Action potential: NW, 94’ «(awe/«WW 04A swam; AM a?! 5 /A€ :a'WZ/ng,‘n has [queasecz :MdMl/g igdgfflgvjmeajw “/2: .1 . NI out a a, "a km W Jam, 6 ' avl‘écfifiift.” ”“79 l “5 “’4 5 2. (20 points). Predict the efi‘ects of the following treatments on action potentials in axons: A drug that blocks volta -gated Na+-channels: W No ac7‘lt914 flo‘finfid A drug that blocks voltage-gated K+-channels: . . . épike (Mr/b 79442 Increases, ire/M /a rig aléléw VJ s/oweg '92 474 kr Away/3 0/4} gage“ LHt'(d 'xtalN): ,. ‘ ‘ (ft; £3121 [1261:122/image36::2%; resting foknfia/w More flgqfirtjflnslwé/zs A/jjm Hypokalemia (a decreaiezn external K): ( Rust/315 pav‘emtv ywrmj Harsh/Clio Aiflerf/éfiar/mknjaviéu I}: more nay/Me A drug that prevents inactivation of voltage-gated Na+—channels: 5% S [be m pl) Me WW5, C(HJ ”491‘ ENC) dung/yen (PMCIP45'6'5," BIPN 100, Mammalian Physiology 1 Name: mam [XE Z Winter, 2008 1St Midterm Exam I.D. #: _ February 1, 2008 Page 2 3. (12 points). While dancing the tango, your partner steps on your toes. You first fell a sharp pain followed by a more diffuse, but persistent pain. Briefly explain the reasons for the time lag between the two types of pain in terms of the sensory fibers that conduct these signals and their properties )0 “‘bFH-gngaim 146W Uta/19 log/if f/bers 50/1/04 flat/e flit/jg elm mek‘l‘ 03” AM ma car/”1404324 [me/ow flflduc'w Awe/r mam M2441 6014134466! (and Alf/Mr] Hie/W 85 am 17,) 066014144040, 6/51/1190 WAG/i A4V€ 31“ llama/er M i)? mu: ddljogé Jflflfif‘éflji jhep WNW (Drawing lad/order gm a [and can/144204 014 § 4 (20 points). For the following ions calculate their equilibrium potential, the driving force in mV for each ion (with the correct sign) and the direction of net movement (in, out, or none) at the corresponding membrane potentials. Assume the respective ion channels are open. [Ion]in: [Ion]out: Eion: Driving force (mV): Driving force (mV): Direction: Direction: (mM) (mM) (mV) Vm=—61mV Vm= +61mV Vm=-61mV Vm= +61mV K= 150 1.5 422 +4; + 1??) 00+ 00+ Na= 14 140 4,4,: -122 o in home Cl=100 10 +4! ”12.2“ 0 . wk 1101a Ca: 0.0001 1 +127. ~ 1‘33 ~61 In 1/14 5. (16 points). The neurons in the hippocampus involved in Long Term Potentiation have 2 excitatory ionotropic synaptic receptors and the brain and the spinal chord have ionotropic inhibitory receptors. List the respective properties of each of the above receptors. Include the neurotransmitter and the ion(s) responsible for the excitation or inhibition: Hippocampus: Receptor: Neurotransmitter: EPSP or IPSP: Ionic selectivity of the channel. i. AMF/i fiIUi‘ammLe. Efgp Nab ii. NMDA fi/ufi male EPSP Nil—l CL‘L‘H‘ Brain: Receptor: Neurotransmitter: EPSP or IPSP: Ionic selectivity of the channel: éABAA GAB/<1 IPsP 0' Spinal chord: Receptor: Neurotransmitter: EPSP or IPSP: Ionic selectivity of the channel: Slfleine 511cm IPSP 61' BIPN 100, Mammalian Physiology 1 Name: AZM Sgfl If? Winter, 2008 1St Midterm Exam I.D. #: February 1, 2008 Page 3 6. (10 points). Parathion is an organophosphate insecticide still used today on some farms to spray rice and fruit trees. Parathion is an acetylcholinesterase inhibitor that is absorbed via the skin and mucous membranes and can cause some serious side effects associated with neural transmission at the neuromuscular junction. a. Which two receptor types would be affected most in a farmer who has been exposed to high 7 1:) amounts ofparathion? NicoflN/C 4 MascA/euwc Ale/7 QECEPTDRS b. Assuming that it is an ionotropic receptor in the synapse above, which ion channel(s) would have an increased conductance as a result of parathion exposure? T0 FLOW WV W96 TN? NlCO‘IM/(C lick RchPTDfl #45 A CHM/UfL 'TMrAway A/4*¢.K‘L 0. Would exposure to parathion most likely cause an increase in EPSP or IPSP in the postsynaptic membrane? Briefly explain your answer. {a EPSP, DécAusf Wm}: close 73 67—UI/lél7UM (5K it; VMJ/ w/kereqj )0 Na‘k [/9 MN. [VJ mile/r? and da/Oo/ar/fixé‘ W 7. (13 points). For the following, please identify the likely area(s) of damage orAfimction. Be specific and indicate sidedness (left/right) when relevant. Becomes active during intense emotion or fear: 4 N/drbfl M A M yap/H, A Glands near the 3rd and 4th ventricles that secrete Cerebrospinal Fluid: C Ala/201; @2703 H Two different areas of the CNS that have no blood-brain barrier: IZPOTNfl—LAHUS P17711178 M 3mm mama/64774 ’ Ventral horns of the spinal chord: M 0 TD ”60,6005 Blindness, although both eyes and optical tracts are normal: 0 cc / P/ 7741 LDB‘E 3 Obesity due to compulsive eating can result from damage to this area: I‘M/100 mm H 015‘ Paralyzed in the ri ht side of the body and cannot talk, but understands read and spoken words: LEW” FRONTNL LaBE Generates respiratory rhythms and regulates cardiovascular activity: MEL!) ULL/Q Dam/MAM Damage causes lack of motor coordination, spastic movements: C?€EBELL UH Contains dopaminergic neurons that inhibit motor pathways. Damage causes tremors and rigidity: BA 54L MNéL/fl Damage causes lack of sensory perception of the left side of the body; reflexes are normal: [9164M— PAR/67241. we; Damage causes loss of memory of recent events only: )—H PPOCAI‘IPUS Lobotomies cause severe personality changes: ' F19 DIV 7m L 0136 ...
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BIPN100midterm1 - BIPN 100 Mammalian Physiology 1 Name A 45...

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