practicefor2 - Biology 20A Spring 2006 Practice questions...

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1 Biology 20A – Spring 2006 Practice questions for Exam 2 May 15, 2006 Briefly state the function of each of the following cellular components 1. lysosome 2. smooth endoplasmic reticulum 3. Golgi apparatus Where does each of the following occur in a eukaryotic cell? Be as specific as possible. 4. Translation of lysosomal proteins 5. Translation of nuclear proteins. 6. Glycolysis. 7. Oxidative decarboxylation of pyruvate 8. Kreb's cycle 9. Transcription 10. Why does lactate build up in some cell types under anaerobic conditions? Use the following to answer questions 11 - 13. 11. Reaction A: a. only occurs during anaerobic conditions b. is coupled to the reduction of NAD+ c. occurs in mitochondria d. is endergonic and must be coupled to ATP hydrolysis e. b and c. 12. Reaction B: a. occurs during glycolysis b. occurs during the Kreb’s cycle c. could be coupled to the reduction of FAD d. b and c e. a and c 13. Reaction C: a. provides an example of substrate-level phosphorylation b. occurs during glycolysis c. occurs during Kreb’s cycle d. is coupled to NAD reduction e. none of the above
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2 14. You are the CEO of a large biotechnology company that is trying to develop drugs that will allow people to eat as much as they want without gaining weight. One of your employees, Dr. Smith, believes that a drug that increases the permeability of the inner mitochondrial membrane to protons would be most effective for controlling obesity. Another employee, Dr. Brown, believes that molecules capable of reducing NADH dehydrogenase might be even more effective. A third employee, Dr. Hyde, vehemently disagrees and recommends the development of drugs that are able to accept electrons directly from cytochrome oxidase. Without considering the potential risk to patients, rank these proposals from most to least promising. Justify your rankings. 15. Briefly compare and contrast the pathways taken by a nuclear protein and a secreted protein from their sites of synthesis to their final destinations. Briefly explain what happens to each protein as it makes its journey through the cell. 16. With the aid of a clearly labeled diagram of a replication fork, clearly explain why Okazaki fragments are generated during the synthesis of the lagging strand. 17. Clearly explain the role of the E, P and A sites of the ribosome during the synthesis of a polypeptide chain. Your answer should include a clearly labeled diagram. What is bound to each site during each step of elongation? You don't need to say anything about translational initiation or termination in your answer. 18. What are the sequences of the primary transcript, mature mRNA and protein encoded by this gene? You do not need to consider any RNA processing events other than splicing in your answer. Be sure to mark the 5' and 3' ends of the RNA and the N and C termini of the protein. Please label the intron and exons in the primary transcript. Use the codon table in your book to help you answer this question.
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This note was uploaded on 04/15/2008 for the course BIO 20a taught by Professor Dalby during the Spring '08 term at UCSC.

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practicefor2 - Biology 20A Spring 2006 Practice questions...

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