3 - Protein Structure and Function Protein structure is...

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Protein Structure and Function Protein structure is based on the amino acid sequence. - polypeptide backbone based on peptide bonds between individual amino acids - reactive side chains off the backbone create the function
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Noncovalent bonds stabilize the polypeptide backbone.
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Noncovalent bonds also create stability in the protein structure based on polarity. Nonpolar side chains – hydrophobic side chains Polar side chaines – hydrophilic side chains
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An example where the hydrophobic amino acid side chains help create structure in the phospholipid bilayer.
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Proteins fold into the conformation with the lowest energy. This is where G, the free energy is the lowest.
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Proteins exist in a given 3-d shape and this is known as the protein’s conformation . When a protein is denatured , it becomes unfolded. Because proteins can renature , one must assume that all the information necessary to specify its specific conformation is contained in the amino acid sequence.
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Within cells there are specialized proteins called molecular chaperones that assist in folding of proteins.
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When the folding of a protein goes wrong, proteins can
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This note was uploaded on 04/13/2008 for the course BIOL 308 taught by Professor Ragsdale during the Fall '07 term at Winona.

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3 - Protein Structure and Function Protein structure is...

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