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Unformatted text preview: •Single nucleotide polymorphisms (SNPs) •Single base substitution that is polymorphic in the population. •3M in human genome, 1 every 300-1000 bases •Combinations of SNPs can be used to identify linkage •Haplotype = chromosome segment defined by an array of SNPs •HapMaps RFLP – restriction fragment length polymorphism •Minisatellites •15-100bp each •basis for original DNA fingerprinting •Digest DNA and use probe for repeat sequence •Offspring inherit bands from each parent •Microsatellite DNA •VNTRs of 2-4 nucleotides in length •DNA typing (paternity/forensics) •Use PCR and flanking primers...
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- Spring '10
- •Single nucleotide polymorphisms