1-notes - 580.221 BME Molecules and Cells L01 Intro to...

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580.221 BME Molecules and Cells L01 Intro to Immunology p 1 Lecture One – Introduction to Immunology GOAL: Molecular binding reactions are critical and their specificity of reactions important. Understanding the chemical, genetic and cellular basis of antibody function motivates the first half of this course. Father of Modern Immunology : Edward Jenner. He noticed that dairymaids exposed to cowpox were resistant to smallpox infection. By infecting a young boy with cowpox , and then observing his resistance to smallpox , Jenner performed the first vaccination ( vaca means cow). Smallpox was eradicated in 1979. Useful Vocabulary (simple descriptions) A. receptor – something that binds a specific molecule (called a ligand); receptors can change their conformation after binding, thus relaying the information that a binding event has occurred. B. ligand – the molecule that specifically binds to the receptor C. antibody – an “adapter molecule” with “2 hands” that bind specifically to a ligand (called an antigen). Antibodies usually (i.e. not in the diseased state) bind only to ‘non-self’ antigens. They have a “torso” region that is similar across the different antibodies; this is what the body can use to recognize all antibodies. D.
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This note was uploaded on 04/15/2008 for the course BME 580.221 taught by Professor Dr.vidal during the Fall '08 term at Johns Hopkins.

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1-notes - 580.221 BME Molecules and Cells L01 Intro to...

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