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Unformatted text preview: 580.221 BME Molecules and Cells L02 Molecular Forces p 1 Lecture Two Molecular forces: Chemical basis of specificity and affinity Outline: chemical foundations (covalent, noncovalent) 4 weak forces importance of pH, pK a , Henderson-Hasselbach equation Molecular Binding The lock and key explanation (unique matching, rigid shapes fit each other) is overly simplistic polymer chain of repeated subunits that are covalently attached. Examples proteins, DNA, RNA (see below). The subunits are called monomers and need not all be identical (e.g. amino acids in a protein) chirality specific 3D arrangement of an atoms shared bonds (more when considering protein structure) Water-Related Reactions condensation reaction in which the release of a water molecule results in the formation of a covalent bond (i.e., making a polymer). Repeated condensation of amino acids results in a chain (polypeptide). hydrolysis reaction in which a water molecule joins another molecule, sometimes breaking up a pre-existing covalent bond (i.e., breaking a polymer). Non-covalent Bonds These are weak forces in cells why? Because in water (cells are mostly water), these forces are weaker than covalent bonds. ...
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