Page1 / 3

2-notes - 580.221 BME Molecules and Cells L02 Molecular...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon

2-notes - 580.221 BME Molecules and Cells L02 Molecular...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
580.221 BME Molecules and Cells L02 Molecular Forces p 1 Lecture Two – Molecular forces: Chemical basis of specificity and affinity Outline: chemical foundations (covalent, noncovalent) 4 weak forces importance of pH, pK a , Henderson-Hasselbach equation Molecular Binding The “ lock and key ” explanation (unique matching, rigid shapes fit each other) is overly simplistic polymer – chain of repeated subunits that are covalently attached. Examples – proteins, DNA, RNA (see below). The subunits are called monomers and need not all be identical (e.g. amino acids in a protein) chirality – specific 3D arrangement of an atom’s shared bonds (more when considering protein structure) Water-Related Reactions condensation – reaction in which the release of a water molecule results in the formation of a covalent bond (i.e., making a polymer). Repeated condensation of amino acids results in a chain (polypeptide). hydrolysis – reaction in which a water molecule joins another molecule, sometimes breaking up a pre-existing covalent bond (i.e., breaking a polymer). Non-covalent Bonds These are weak forces in cells – why? Because in water (cells are mostly water), these forces are weaker than covalent bonds. This is not necessarily true in a different environment. You should
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.
Ask a homework question - tutors are online