2-notes - 580.221 BME Molecules and Cells L02 Molecular...

Download Document
Showing pages : 1 of 3
This preview has blurred sections. Sign up to view the full version! View Full Document
580.221 BME Molecules and Cells L02 Molecular Forces p 1 Lecture Two – Molecular forces: Chemical basis of specificity and affinity Outline: chemical foundations (covalent, noncovalent) 4 weak forces importance of pH, pK a , Henderson-Hasselbach equation Molecular Binding The “ lock and key ” explanation (unique matching, rigid shapes fit each other) is overly simplistic polymer – chain of repeated subunits that are covalently attached. Examples – proteins, DNA, RNA (see below). The subunits are called monomers and need not all be identical (e.g. amino acids in a protein) chirality – specific 3D arrangement of an atom’s shared bonds (more when considering protein structure) Water-Related Reactions condensation – reaction in which the release of a water molecule results in the formation of a covalent bond (i.e., making a polymer). Repeated condensation of amino acids results in a chain (polypeptide). hydrolysis – reaction in which a water molecule joins another molecule, sometimes breaking up a pre-existing covalent bond (i.e., breaking a polymer). Non-covalent Bonds These are weak forces in cells – why? Because in water (cells are mostly water), these forces are weaker than covalent bonds. This is not necessarily true in a different environment. You should
Background image of page 1
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Create a FREE account now to get started. Log In

The email address you entered is not valid. The email address you provided is already in use.
Your username must be at least 5 characters. Your username must consist of only alphanumeric characters. Your username must contain at least one letter. Your username contains inappropriate language. Another user has already claimed this username.
Your password must be at least 6 characters in length.
{[ $select.selected.label ]} Please select a valid school.
By creating an account you agree to our Privacy Policy, Terms of Use, and Honor Code.
Create my FREE account Processing...
Sign Up with Facebook

We will never post anything without your permission.

Already on Course Hero? Log In