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6 - Kuo 580.221 21 Sept 2004 Concepts/Vocabulary Molecules...

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Kuo, 580.221 21 Sept 2004 1 Molecules & Cells BME 580.221 Nucleic Acids Lecture #06, 21 Sep 2004 Scot C. Kuo 21 Sept 2004 Kuo, 580.221 Concepts/Vocabulary Structure = Function; amino acid sequence determines structure DNA & RNA determine aa seq (Central Dogma) Specificity of base-pairing: same weak forces as in protein structure Review: structure of RNA & DNA; replication of DNA Transcription & Translation 21 Sept 2004 Kuo, 580.221 Structure of Nucleic Acids Sugar backbone 21 Sept 2004 Kuo, 580.221 Structure of Nucleic Acids Principal Bases 21 Sept 2004 Kuo, 580.221 Naming Nucleo s ides (lack s phosphate) and Nucleo t ides (nucleoside with 5’ phospha t es) add cartoon from Lehninger? 21 Sept 2004 Kuo, 580.221 Nucleic Acid Chains
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Kuo, 580.221 21 Sept 2004 2 21 Sept 2004 Kuo, 580.221 DNA double helix Strands are antiparallel 21 Sept 2004 Kuo, 580.221 H-bond & Complementary Base Pairs 21 Sept 2004 Kuo, 580.221 DNA double helix detail 21 Sept 2004 Kuo, 580.221 Show QTV of nucleic acid struct 21 Sept 2004 Kuo, 580.221 Models of DNA helices 21 Sept 2004 Kuo, 580.221 Protein binding can deform DNA
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