7 - Kuo 580.221 23 Sept 2004 1 Molecules& Cells BME...

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Unformatted text preview: Kuo, 580.221 23 Sept 2004 1 Molecules & Cells BME 580.221 Genetic Transcription & Translation Lecture #07, 23 Sep 2004 Scot C. Kuo 23 Sept 2004 Kuo, 580.221 Concepts/Vocabulary • Key role of RNA: – mRNA - messenger RNA – tRNA - transfer RNA (adapter molecule) – rRNA - ribosomal RNA • Vocabulary: Transcription, Translation • Start/Stop/Regulation: comparison between Replication, Transcription & Translation 23 Sept 2004 Kuo, 580.221 Central Dogma of Molecular Biology • DNA->RNA->protein • All cells, from bacteria to human, express genetic information this way. 23 Sept 2004 Kuo, 580.221 Rules for Protein & Nucleic Acid Synthesis • There are a limited number of different monomeric building blocks. • Monomers are added one at a time. • Each chain has a specific starting point. Growth proceeds in one direction. There is a fixed and specific terminus (‘stop’). • The primary synthetic product is often modified. 23 Sept 2004 Kuo, 580.221 Processes in Molecular Biology, so far Stop Start Enzymes Subunit Process, Directionality Polym. Translation N → C (amino → carboxyl) protein RNA pol., etc. Transcription 5’ → 3’ RNA (mRNA tRNA rRNA) Origin of replication; (lag: RNA primer) DNA pol., ligase, etc. (repair) d NTPs Replication 5’ → 3’ DNA 23 Sept 2004 Kuo, 580.221 3 Roles for RNA in Gene Expression • Messenger RNA (mRNA) - copy of genetic information from DNA • Transfer RNA (tRNA) - decodes mRNA...
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7 - Kuo 580.221 23 Sept 2004 1 Molecules& Cells BME...

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