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Unformatted text preview: Kuo, 580.221 23 Sept 2004 1 Molecules & Cells BME 580.221 Genetic Transcription & Translation Lecture #07, 23 Sep 2004 Scot C. Kuo 23 Sept 2004 Kuo, 580.221 Concepts/Vocabulary Key role of RNA: mRNA - messenger RNA tRNA - transfer RNA (adapter molecule) rRNA - ribosomal RNA Vocabulary: Transcription, Translation Start/Stop/Regulation: comparison between Replication, Transcription & Translation 23 Sept 2004 Kuo, 580.221 Central Dogma of Molecular Biology DNA->RNA->protein All cells, from bacteria to human, express genetic information this way. 23 Sept 2004 Kuo, 580.221 Rules for Protein & Nucleic Acid Synthesis There are a limited number of different monomeric building blocks. Monomers are added one at a time. Each chain has a specific starting point. Growth proceeds in one direction. There is a fixed and specific terminus (stop). The primary synthetic product is often modified. 23 Sept 2004 Kuo, 580.221 Processes in Molecular Biology, so far Stop Start Enzymes Subunit Process, Directionality Polym. Translation N C (amino carboxyl) protein RNA pol., etc. Transcription 5 3 RNA (mRNA tRNA rRNA) Origin of replication; (lag: RNA primer) DNA pol., ligase, etc. (repair) d NTPs Replication 5 3 DNA 23 Sept 2004 Kuo, 580.221 3 Roles for RNA in Gene Expression Messenger RNA (mRNA) - copy of genetic information from DNA Transfer RNA (tRNA) - decodes mRNA...
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