Bios213 lecture 13 - DISEASES ASSOCIATED WITH TOXIN PRODUCTION 1 Diphtheria 2 Botulism 3 Tetanus 4 Anthrax 5 Cholera Corynebacterium diphtheriae

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DISEASES ASSOCIATED WITH TOXIN PRODUCTION 1 Diphtheria 2 Botulism 3 Tetanus 4 Anthrax 5 Cholera
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Corynebacterium diphtheriae – diphtheria
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ADP-ribosylation of Elongation factor 3 Shuts down translation Mechanism of action of diphtheria toxin
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Clostridium botulinum – Botulism Clostridium tetani – tetanus Both anaerobic organisms Both elaborate neurotoxins
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Nerve synapse – release of acetyl choline Relaxation of nerve synapse – release of glycine
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Botulism toxin Neurotoxin – prevents release of acetyl choline
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Tetanus toxin - neurotoxin Prevents release of glycine No relaxation of nerve synapse
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Bacillus anthracis
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Anthrax toxin PA – protective antigen EF – edema factor LF – lethal factor
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Cholera Caused by Vibrio cholerae Current pandemic Pathology caused by the expression of an entertoxin Effect messes up cAMP levels in mucosal cells in gastrointestinal tract
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AB toxins - Cholera toxin 5 B subunits 1 A subunit
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Cholera toxin - enterotoxin Causes massive movement of Cl ions and water into lumen
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This note was uploaded on 04/09/2008 for the course BIOS 231 taught by Professor Hill during the Spring '08 term at Northern Illinois University.

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Bios213 lecture 13 - DISEASES ASSOCIATED WITH TOXIN PRODUCTION 1 Diphtheria 2 Botulism 3 Tetanus 4 Anthrax 5 Cholera Corynebacterium diphtheriae

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