Bioterror lecture - BIOTERRORISM Factors that influence...

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BIOTERRORISM
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Factors that influence disease transmission correct portal of entry dose host defenses
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transmission respiratory/aerosol e.g. smallpox, pulmonary anthrax, tularemia, melioidosis, psittacosis, Q fever fecal / oral route e.g. brucellosis, Escherichia coli O157:H7 water contamination e.g. cholera, cryptosporidiosis vectors e.g. plague, viral hemorrhagic fevers, viral encephalitis, typhus fever potential bioterrorist routes
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Factors that influence disease transmission correct portal of entry e.g. subcutaneous vs. lung infection - anthrax dose e.g. 10,000 spores required for lung infection host defenses
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Host defense mechanisms chemical / physical barriers phagocytic cells - macrophages - neutrophils lymphatic system - delivery of infectious agents to fixed phagocytic cells inflammatory response - recruitment of phagocytic cells to site of infection - mucosal epithelium vulnerable - often exploited by pathogenic organisms
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cont. active immunity
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Bioterror lecture - BIOTERRORISM Factors that influence...

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