Phys-Test-3 - TEST 3 E Blood(“whole blood” 1 Components...

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Unformatted text preview: TEST 3 E) Blood (“whole blood”) 1) Components A) Plasma- liquid portion B) Formed elements- RBC’s, WBC’s, and platelets (cell fragment) 2) Plasma- 92% water A) Function- solvent or suspension medium; contains dissolved chemicals; transport in CV system throughout body B) Soluble constituents (1) Plasma proteins- 7% of plasma (a) Types (i) serum albumin- 60% of proteins (highest concentration, smallest in size) (ii) serum globulins- 36% of proteins a.-1-globulins (alpha)- made by liver α b.-2-globulins (alpha)- made by liver α c.-globulins (beta)- made by liver β d.-globulins (gamma)- antibodies; make by plasma cells γ (iii) Prothrombrin- associated with blood clotting; made by liver (iv) Fibrinogen- associated with blood clotting; made by liver (b) Functions (i) Maintenance of osmotic balance between blood plasma and all tissue fluids (Starling-Landis Law of the capillaries) a. Forces involved 1 hydrostatic pressure of blood- force exerted by blood pressure on walls of blood vessels 2 colloid osmotic pressure of blood- determined by concentration of proteins in blood plasma; albumin is largely responsible for osmotic pressure because of the quantity b. Mechanism for fluid exchange 1 influence of hydrostatic pressure • high at arteriole end of capillaries; causes fluid to flow into tissue spaces from capillaries; becomes reduced at venule end 2 influence of colloid osmostic pressure (COP) TEST 3 • low at arteriole end of capillaries; fluid lost though capillaries but proteins are retained; COP is higher at venule end because proteins are more concentrated • fluid moves back into capillaries from tissues • COP is high, so it pulls the fluid back in to maintain blood volume • If this didn’t happen, blood pressure would drop dramatically (ii) Regulation of Blood pH a. Can react with H+ [H+ ] reduced (iii) Transport of lipid substances in blood plasma by lipoproteins ( -1-globulins, -2-globulins, and -globulins) α α β a. Lipid substances- cholesterol, triglycerides, steroid hormones, and fat soluble vitamins (A, D, E, and K) (iv) Protection against infection a. Specific -globulins (antibodies) combine with antigenic γ substances (microorganisms, toxins and other antigenic chemicals) to stimulate their destruction (v) Blood clotting a. Elaborate set of biochemical reactions which include prothrombrin, fibrinogen, and other plasma proteins that convert blood from fluid (sol) to semisolid (gel) (2) Other Chemicals- 1% of plasma (a) Non-Protein Nitrogenous (NPN) Substances (i) Urea- waste product of protein metabolism (ii) Uric acid- (iii)Creatine- (b) Organic Nutrients (i) Glucose- most common sugar (ii) Amino acids- building blocks of proteins...
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This note was uploaded on 04/15/2008 for the course BIOL 20214 taught by Professor Barcellona during the Spring '08 term at TCU.

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Phys-Test-3 - TEST 3 E Blood(“whole blood” 1 Components...

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