04_05_07 - Mutations mutagenesis and repair...

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Mutations: mutagenesis and repair Mutations-heritable change in DNA. Most of the times the damage is a lesian, some kind of DNA damage that creates and non standard nucleotide, or a non standard structure in DNA. Not heritable, because DNA pol can’t incorporate into the new strand. Lesian on one strand of the DNA could often cause a mutation in the other strand of DNA during replication. Different types of mutation. Spontaneous mutation: sometimes one of the bases simply breaks on its own. This is called an lesian since the new structure is a non standard structure called apurinic site. Or ap site. A pyrimidine could leave and it’s called a apyrimidic site(AP site) Most of the time when there is an AP site on one of the strands the DNA pol will dissociate from the template, and reassociate with the a new primer. A gap is formed and the gap is an impediment to the completion of the replication. A mutation will result under special circumstances to be defined later. Under the
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This note was uploaded on 04/15/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas.

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04_05_07 - Mutations mutagenesis and repair...

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