GenNotes4_5 - Genetics Notes 4-5 Mutagenesis- where...

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Genetics Notes 4-5 Mutagenesis- where mutations come from (often from lesions) Repair- how cells fix mutations. I. Mutagenesis A. Spontaneous mutations- not cause by outside chemicals, etc. 1) apurinic and apyrimidinic sites (AP sites) apurinic site apyramidic site a. To form an AP site the bond breaks between deoxyribose and the base. b. Since the base is now only attached by an H bond to the complementary base that bond is not strong enough to keep it there and it leaves. c. Apurinic & apyrimidic sites are both called AP sites (since it is the same thing without a base). d. IS a lesion but doesn’t usually lead to a mutation because DNAp disassociates and moves downstream letting the site be fixed later. e. In “special circumstances”, DNAp picks up a random nucleotide and continues replication-this causes a substitution or it doesn’t put any base and continues replication-this causes a one nucleotide deletion . 2) Replication slippage (NOT a lesion)- The two strands slide along each other.
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GenNotes4_5 - Genetics Notes 4-5 Mutagenesis- where...

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