1_23 - Franklin’s model was correct(after stealing it...

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1/23 DNA a phosphate group + sugar (ribose or deoxyribose) + base (A,G,C,T) Bases attach to the 1’ carbon Phosphates attach to the 5’ carbon DNA strands have covalent bonds between nucleotides using phosphodiester bonds. Electro negativity with hydrogen helps keep the antiparallel strands together. Chargraff’s Rule No constant pattern in nucleotides between species create different amounts of A,G,T and C. So A=T and G=C Roselyn Franklin – x-ray diffraction was her specialty and she could see the figure that indicated the double helix shape of DNA. Watson and Crick – Put the DNA model together. They proved Chargraff’s rule and proved that
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Unformatted text preview: Franklin’s model was correct (after stealing it). Strands that are bonded are antiparallel. 5’-3’ vs. 3’-5’. The major groove > the minor groove. See image. Proteins are too large to fit into the grooves, and so it has appendages that make contact with bases. Amino acids that pair with the bases help the protein appendages to bond properly. B DNA is the general form of DNA found in cells. Right-handed DNA – Spirals in upward, right directions Left-handed DNA – Spirals to the left and is very rare. Z DNA has less and different grooves. It interacts differently with proteins as well....
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