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07Mutagens_Rep_1 - H-– mismatch repair C C –...

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Mutation: Mutagenesis and Repair this base sometimes breaks ^AP site * Mutagenesis spontaneous mutations apurinic & apyrimidinic sites (AP sites) replication slippage ^ APyr site tautomeric shifts mutagens: radiation ultraviolet radiation before after bckwd slip after fwd slip pyrimidine dimers mutagens: chemicals deaminating agents: e.g., nitrous acid 1.) ^1.) ^1.) alkyating agents: e.g., nitroso compounds ^2.) ^2.) intercalators: e.g., ethidium bromide Repair of mutations C. direct repair . by alkyltransferases T---H-- by photoreactivation enzyme (PRE) A excision repair of dimers by uvrABC endonuclease of AP sites by AP endonuclease of deaminated bases by glycosylases A of mismatches by MutS and MutH post-replication repair G------
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Unformatted text preview: H----– mismatch repair C C – recombination “repair” by RecA o error-prone systems TRANSITION – SOS lesion bypass – LexA – UmuC, UmuD T – DNA polymerases zeta ( ζ ) and eta ( η ) C---G G Ames test for mutagenicity TRANSITION A T G T TRANSITION 11 sugar N O H N N N N H N N O H 3 C H 3 C H 3 C • sugar H 2 N O H N N sugar H 2 N O sugar H 2 N O H H 3 C sugar H 2 N O H CH 3 N N N N N N N N N N N N N N N N N N H 2 N N N N N H 2 N O O N N H O O N N H N N N N H 2 N N N N N H 2 N O O N N H O O N N H sugar N O N sugar H 2 N O H N N N N O sugar N O N H CH 3 NH sugar N O N H sugar H 2 N OH N N N N sugar NH N N N N H OH sugar N O N CH 3 sugar N N N N N H H N H H 12 sugar N O N N H H O sugar N O N H CH 3...
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