04_10_07 - Mutagens UV causes the double bond on thymines...

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Mutagens UV causes the double bond on thymines to be excited and generate 2 single bonds that connects two adjacent thymines. It is a lesion. The distance of the bond length draws the two thymines closer, this moves them out of position for hydrogen bond formation. During replication DNA pol can’t pick up anything that would base pair with the thymine so the DNA pol dissociates. The DNA pol will associate somewhere down stream and forms a gap. Under special circumstances, the pol doesn’t dissociate and picks up an random nucleotide, and adds it on to the 3’ end, and moves on to the next nucleotide, and places another random nucleotide since it is still a part of the dimmer. A substitution occurs. The DNA pol might also might just pick up one random nucleotide, and reads the dimmer as 1 nucleotide, and skips the second part of the dimmer. A deletion occurs. This should remind you of an AP site. Chemical mutagens:
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This note was uploaded on 04/15/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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04_10_07 - Mutagens UV causes the double bond on thymines...

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