05Pathways - Translation, continued Connecting genotype to...

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Translation, continued Connecting genotype to phenotype Archibald Garrod - Gene expression – process by which a gene’s nucleotide sequence manifests in an organism’s genotype Garrod – black urea disease – rare disease; they were related; reason for their different phenotype, they had different genotypes from other people, they share it with each other. If their urine is different, then its because there is different chemicals in their urine because their metabolism is different. There is some metabolic reaction that occurs in most people that don’t occur with them. That’s what genes do. Was trying to connect genotype and phenotype. Define what genes were actually doing. Garrod said genes control metabolism. alkaptonuria – black urea disease; most people convert phenylalanine to tyrosine, but people with alkaptonuria does not do so. PKU - If tyrosine doesn’t occur, then there is a deficiency and an increase of phenylalanine (toxicity of the substrate). Causes the adverse phenotype. Is it the
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This note was uploaded on 04/15/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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05Pathways - Translation, continued Connecting genotype to...

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