5_Pathways__cont_ - subunits that code for different genes...

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Translation, continued on 2/20/07 Connecting genotype to phenotype Archibald Garrod alkaptonuria biochemical pathway substrate, end product intermediate o Won Nobel Price in 1940 for t he idea was that each locus controlled the production of a unique enzyme.” “One gene, one enzyme hypothesis” – next: exception o Each gene makes a SINGLE protein, and that protein catalyzes a single biochemical process. But it was FALSIFIED : cause some genes code for RNA post transcription of proteins continue with extrons and introns o A gene can be transcribed to produce an mRNA to get the “one-gene-one- enzyme”, o transcription factors o it can code only PART of an enzyme, like if it was made of a lot of
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Unformatted text preview: subunits that code for different genes • one gene, one polypeptide hypothesis o a gene codes for one specific peptide o alternative splicing makes it NOT 1:1 o one gene can code for less than one peptide? Yes! It can code to become an rRNA or a tRNA, etc. o genes will become a polypeptide or one or more rRNA’s BIOCHEMICAL PATHWAY Phenylalanine substrate, toxicity of substrate phenylalanine hydroxylase (intermediate) tyrosine deficiency of product tyrosine transaminase (intermediate) p-hydroxyphenylpyruvic acid p-hydroxyphenylpyruvic acid oxidase (intermediate) homogentisic acid (gene H) homogentisic acid oxidase 4-maleylacetoacetic acid (end product)...
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