2_20 - lecture 2/20/07 Mutation Basics Mutation- heritable...

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lecture 2/20/07 Mutation Basics Mutation- heritable change in the genetic material. A change in your RNA is not a mutation- it is not a change in your genetic material. Anything that has to do with viruses that don’t have DNA as their genetic material (RNA instead), changes in the RNA ARE MUTATIONS. “Heritable” doesn’t have to be from one generation to the next; it may just be from mother cells to daughter cells. Think “copyable” by DNA polymerase. What kind of change can it copy? Different orders of G, A, T, C. Different orders, different numbers. Changes in nucleotide sequences. Point mutations from the DNA perspective Changes that occurs at a point, at a small location. A point mutation affects one nucleotide or one base pair. This matters during replication! The change that happened in one nucleotide is copied over into the other strand. DIFFERENT KINDS OF POINT MUTATIONS: Substitution- does not change the number of nucleotides. It just changes what nucleotide is there. KINDS OF SUBSTITION: Transition (more common by far)- turn a pyrimidine into another pyrimidine, and a purine into another purine. Transversion-
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This note was uploaded on 04/15/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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2_20 - lecture 2/20/07 Mutation Basics Mutation- heritable...

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