student notes lecture 24

student notes lecture 24 - Chem 11500 Lecture 24, External...

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Click to edit Master subtitle style 11 Chem 11500 Lecture 24, External readings; p. 732; pp 698-699. See the course website Sections 13.6-13.8, pp 616-629, and pages 84-86, p. 1052 and figure 21.28 on p. 1053. Read also http://pubs.acs.org/hotartcl/mdd/00/mar/knap. html “Polymorphic Predictions”
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22 Malaria Malaria is caused by parasitic protozoa (genus: Plasmodium) and is transferred to humans by mosquitos. Symptoms: VERY high fever (107°F), nausea, delirium There are an estimated 100 – 200 MILLION cases of malaria worldwide each year (80% are in Africa) 1 – 1.5 millions deaths per year
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33 Malaria Parasites reproduce in the liver then in red blood cells
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44 Treatment of Malaria: Quinine Before the arrival of European settlers, Peruvian Indians used bark from the Cinchona tree (found in the Andes) to treat fever; it also was found to cure malaria. Europeans learned about the healing ability of Cinchona bark and started harvesting it (almost to extinction, but for the development of conservation efforts) and sending it back to Europe.
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55 Treatment of Malaria: Quinine The active ingredient in the Cinchona bark is quinine, isolated in 1820. Quinine cures malaria by killing the parasite (it binds to proteins in the body that the parasites need.) eerily nicotine like, isn’t it?
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66 Many drugs are discovered in the same way as quinine Aspirin – salicylic acid (not aspirin) was obtained by chewing on Willow bark. Alfred Bayer in Germany discovered that the acetyl ester was more effective for pain relief, and called it “aspirin” (the trademark was lost when the US seized all domestic German assets after WWI).
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77 Many drugs are discovered in the same way as quinine Mold in a petri dish led to the discovery of penicillin. Countless potential drugs are isolated from plants, algae, and even things like sea sponges.
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88 This approach to drug discovery is what chemical biologists call “Forward Chemical Genetics” Reduces Fever Aspirin Cyclooxegenase 2 Forward chemical
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This note was uploaded on 01/20/2009 for the course CHM 115 taught by Professor Towns during the Fall '08 term at Purdue University.

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student notes lecture 24 - Chem 11500 Lecture 24, External...

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