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bis_104_pq_11_ans_fall_08 - used as a marker to identify...

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BIS 104 Practice Question 11 11. Mukouyama et. al. use the erbB3 mutant, a mouse strain that lacks Schwann cells, to demonstrate that Schwann cells are required for arterial differentiation and blood vessel-nerve alignment. What is the function of the signaling molecule Neuregulin-1? Neurugulin-1 is a signaling factor produced by neurons. It acts on the erbB3 co-receptor on Schwann cells. This interaction is required for the development and survival of Schwann cells. How is the marker known as BFABP (brain fatty acid binding protein) used in these erbB3 studies? BFAP is a protein that is produced only by differentiated Schwann cells and therefore, can be
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Unformatted text preview: used as a marker to identify them. Fluorescently labeled antibodies against BFABP are used to verify the presence of Schwann cells in normal tissue and their absence in the skin tissue in erbB3 mutant mice. Why was it important in these studies to show that erbB3 is not normally expressed in endothelial cells as they differentiate? It must be remembered that in the erbB3 mutant strain of mice, the erbB3 gene is defective in all cells of all tissues, not just in the Schwann cells. So the failure of arteriogenesis in erbB3 mice could also be explained if endothelial cells themselves need to express the erbB3 gene for their normal differentiation....
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