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lect_9proteintraffic2slides_08W

lect_9proteintraffic2slides_08W - Protein Trafficking This...

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1 Protein Trafficking This the the cellular process whereby the many different types of proteins are localized to the correct place in the cell be it cell membranes or cell compartments like the nucleus or mitochondria. Also known as protein sorting or protein targeting . Protein trafficking
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2 How are proteins Targeted? By signal sequences, that is, sequences of amino acids on the N-terminal end specific for a particular organelle.
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3 Overview Signal sequences
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4 Targeting proteins into mitochondria Mitochondrial Uptake sequences
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5 Uptake requires recognition proteins and free energy to prevent protein and provide membrane attachment folding 1. Energy source- ATP 2. Chaperones and mitochondrial- import stimulating factor (MSF) Heat shock proteins act as ‘folding and unfolding’ police Molecules that ferry molecules to various places within cells
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6 Energy needed Two paths for attach- ing Proteins must be unfolded to enter mitos Contact sites Antibody binding
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7 Submitochondrial targeting
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