lect_13cellcycle2slide_05W

lect_13cellcycle2slide_05W - controls mitosis Cyclin must...

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1 Cell Cycle 1. A collection of highly ordered processes X n where n = 1,2,3,4,…. . 2. Discrete transitions 3.Transitions X n are unidirectional. Change shifts cell from one set to another. 4. Transition to X n is inhibited until X n-1 is completed. Design by check-points Mitosis in eukaryotic cells
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2 Mitotic Apparatus Kinetics of Spindle action
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3 Cell activities during mitosis triggers Mutated Growth factor receptors can cause uncontrolled division. Valine Glutamine neu found in some types of breast cancer
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4 Mitosis divided into functional phases interphase division How are phases determined? Biochemically
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5 Check Points Design of check points 1. detector 2. signal 3. effector
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6 Discovery of the cell cycle motor Maturation Promoting Factor (MPF) MPF and homologues cdc’s are Kinases
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7 Cdc2 kinase activity oscillates What causes the motor protein to oscillate ? 1. Amount 2. Activity Discovery of cyclin
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8 The Amount of Cyclin Oscillates during cell cycle Cyclin mRNA has MPF activity
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9 The cyclin machine. An oscillator Cyclin synthesis and destruction
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Unformatted text preview: controls mitosis Cyclin must be destroyed 10 Regulation of MPF by cyclin B, kinases, and Phosphatases Kinases-Wee1 and CAK-Cdc-activating kinase Phosphatases- Cdc 25 Mutants in yeast useful for studying Cdc2 11 Biochemical model of cell cycle engine Computer model of cell cycle 12 Proteolytic pathways drive cell cycle 1. Cyclin like other proteins has a ‘destruction box’- sequence of amino acids 2. Ubiquitin (76 aa protein) is added. 3. Ubiquinated proteins are shuttled to destruction complexes Disintegration of nuclei during mitosis due to Cdc kinase action on lamins 13 Functions of cdc-cyclin In multicellular organisms, the number of cell Is tightly regulated, not only by controlling cell division, but by regulating cell death. Often cells commit suicide by activating a death program. This process is called programmed cell death or apoptosis . Programmed Cell Death 14 Apoptosis Apoptosis is regulated by Bcl-2 family...
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This note was uploaded on 01/24/2009 for the course MCDB 100 taught by Professor Olague during the Winter '07 term at UCLA.

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lect_13cellcycle2slide_05W - controls mitosis Cyclin must...

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