lect_15cancer2slide_06W

lect_15cancer2slide_06W - Cancer The role of viruses,...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Cancer The role of viruses, proto-oncogenes, oncogenes, and mutation What is cancer? 1. It is a cell-cycling disease 2. It is a somatic cell disease. (genetic, but usually not inherited) 3. It is many diseases with different molecular causes.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 What are general differences between normal and cancer cells? Certain DNA viruses produce transformed cells
Background image of page 2
3 RNA viruses produce cell transformation. 1. These viruses are called retroviruses 2. Single or double stranded RNA 3. They use reverse transcriptase to replicate inside cells 4. They integrate into genomes Evidence that viruses can cause transformation, a model for cancer cells 1. In 1910 Peyton Rous isolated filtrate that caused tumors in chickens 2. Find viral genes in cancer cell genome.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 What type of viral genes produce transformed cells? How do viral genes produce tumors? By altering control of cell cycling
Background image of page 4
RNA tumor virus architecture and integration. Viral genes
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 14

lect_15cancer2slide_06W - Cancer The role of viruses,...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online